Pharmacological modulation of postoperative pain relief in oncology patients by anesthetic drugs based on clinical data

Abstract

Objective: Based on clinical data, to study the effect of different anesthetic drugs on pharmacological modulation of postoperative pain relief in oncology patients. Methods One hundred twenty-six oncology patients who underwent surgery in a tertiary hospital from January 2020 to January 2024 were retrospectively selected as study subjects, and three anesthetic analgesic regimens of opioid analgesia, local anesthetic analgesia, and combined analgesia were used to record the pain scores (VAS scores) at 30min, 1h, 3h, 6h, 12h, 24h, and 48h postoperatively, as well as the patient's 24h postoperatively The number of self-controlled analgesia (PCIA) presses and analgesic remedy rate were recorded. Results The VAS scores of the composite analgesia group were lower than those of the other two groups at all postoperative time points, and the differences were statistically significant from 30 min to 6 h postoperatively (P<0.05). There were significant differences in the number of PCIA presses and analgesic remedy rates among the three groups in the 24h postoperative period (F=7.45, 8.92, P=0.001, 0.000). The analgesic remedy rate of 15.2% in the compound analgesia group was significantly lower than that of 28.6% in the opioid analgesia group and 34.9% in the local anesthetic analgesia group, P<0.05. Conclusion Based on the analysis of clinical data, the composite analgesic regimen can enhance the analgesic effect while reducing the use of opioids, lowering the risk of related adverse reactions, and improving patients' postoperative comfort.