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Pengwei Zhu
This research project aims to explore and understand the mechanisms associated with the pathogenesis of BD through specific aims: Develop a standard analytic pipeline for preprocessing and analyzing BCNs using rs-fMRI data and clinical and demographic records from the Adolescent Brain Cognitive Development (ABCD) study. This will allow us to quantitatively understand the cognitive development of adolescents with BD, ultimately improving diagnosis and treatment for this population. The goal of this research project is to address critical issues in the preprocessing and analysis of rs-fMRI data to enhance our comprehension of BD, develop more accurate methods for diagnosis and treatment, and reduce the public health impact of this disorder.
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Yuqian Zhao, Jing An, Huaqing Liu, Huiqin Ding
Objective This study aimed to explore the effect of structured psychological nursing intervention based on psychological capital theory on the psychological state of patients in the Intensive Care Unit (ICU) and the mental health of their families. Methods A randomized controlled trial design was adopted. A total of 120 conscious patients with an expected length of stay in the ICU of ≥7 days and 240 primary caregiving family members admitted to the ICU of a Grade A tertiary hospital from January to December 2023 were selected as the research subjects. They were randomly divided into an intervention group and a control group, with 60 patients and 120 family members in each group. The control group received conventional psychological nursing, while the intervention group implemented a structured psychological nursing intervention program based on psychological capital theory in addition to conventional nursing. Evidence-based nursing techniques such as goal-setting technology, cognitive restructuring method, positive suggestion therapy, and stress coping training were adopted. Each intervention lasted for 30-45 minutes, was conducted once every other day, and a total of 6 interventions were carried out. The intervention period was from 48 hours after admission to the ICU until before transfer out of the ICU. Results After the intervention, the score of the Psychological Capital Questionnaire of patients in the intervention group was significantly higher than that in the control group (42.85±6.12 vs 36.24±5.78, P<0.001), and the scores of the Hamilton Anxiety Scale and Hamilton Depression Scale were significantly lower (Anxiety: 8.45±3.21 vs 12.67±4.15, P<0.001; Depression: 7.92±2.89 vs 11.43±3.67, P<0.001). The psychological capital score of family members in the intervention group was significantly higher than that in the control group (45.76±7.23 vs 38.92±6.45, P<0.001), and the score of the Zarit Caregiver Burden Interview was significantly lower (28.34±5.67 vs 35.28±6.92, P<0.001). Conclusion The structured psychological nursing intervention based on psychological capital theory can effectively improve the mental health status of ICU patients and their families, and enhance their psychological adaptability and coping efficacy.
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Chunmei Yang, Xiaojing Ma, Congcong Zhang
This research explores how using a birthing ball alongside free positioning enhances the childbirth experience and outcomes for first-time mothers. A randomized controlled trial was conducted involving 200 nulliparous women, equally divided into an intervention group utilizing both birthing balls and free positions, and a control group following conventional supine delivery methods. Findings revealed that the intervention group experienced a notably shorter first stage of labor, averaging 5.8 hours compared to the control group's 7.2 hours. Additionally, the incidence of perineal injuries was reduced to 25% versus 41% in the control group. Pain levels, measured by VAS scores, were significantly lower at 6.2 points compared to 7.5 points in the control group. Maternal satisfaction rates also improved, reaching 82% in the intervention group against 65% in the control group. These results demonstrate that integrating birthing balls with free positioning effectively shortens labor duration, decreases perineal trauma, alleviates pain, and boosts maternal satisfaction, highlighting its clinical applicability. The study offers valuable scientific evidence and practical insights for optimizing delivery experiences among nulliparous women.
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Qiongwen Xu, Bo Jin
The histone modification H3K4me3 plays an important role in regulating gene expression and displays extensive reprogramming on the genome during critical stages of mammalian embryonic development. In this study, we collected porcine oocytes and early fertilized embryos at various stages, and used immunofluorescence staining as well as low-cell-volume chromosome immunoprecipitation sequencing to investigate the changing pattern of key histone modification H3K4me3 during the development of early fertilized porcine embryos. The methylation levels of porcine germ cells with in vivo embryos at different developmental stages were detected by RRBS method. The HOT of embryonic stem cells (H1) to middle endoderm cells (ME), neural precursor cells (NPC), trophoblast cells (TBL), and mesenchymal stem cells (MSC) was analyzed by in-depth investigation of the dynamic law of change of the genetic traits (HOT) during the development and differentiation of embryonic development in the critical period. The results showed that the failure of H3K4me3 broad to narrow peak conversion on the promoter of ZGA-related genes at the 4-Cell stage in the knockdown group was detected by immunofluorescence staining as well as ChIP-seq. These results suggest that H3K4me3 affects early embryonic development mainly by influencing the occurrence of ZGA and thus the development of the early embryo, further suggesting the role of genetic traits in the critical period of porcine embryonic development.
